HN Theater @HNTheaterMonth

Heh. That was the first thing that popped to mind too. But it might be best to avoid the topic.

Still, genetic engineering is marching ever-closer. https://www.youtube.com/watch?v=jAhjPd4uNFY

For the surely upcoming discussion about pros and cons of genetic editing in humans, Kurzgesagt has a basic overview of the space, if you can spare some 15 minutes with your morning coffee.

https://www.youtube.com/watch?v=jAhjPd4uNFY

(not affiliated, just love their videos)

Many new immune system tools are being developed. MinION is now used for T-Cell and B-Cell characterization by reading immune response to breast cancer. Can you create a AS model? https://www.biorxiv.org/content/biorxiv/early/2018/09/24/424...

I can send a model, Python DNA Plotter, of an Oxford nanopore DNA sequencer(MinION), shows what a Mu DNA plotter simulation may look like.

Students can now learn python programming and DNA sequencing in school, using Mu python to simulate MinION. NMSU is using MinION:https://www.youtube.com/watch?v=9tUtC4rcZ3w​

MinION, how it works video:https://www.youtube.com/watch?v=GUb1TZvMWsw Python is the most widely used computer language: https://codewith.mu/​ https://codewith.mu/en/tutorials/1.0/plotter A cheap $1K sequencer, MinION, models immune response to immunotherapy? https://blogs.rstudio.com/tensorflow/posts/2018-01-29-dl-for...

Can we then create a cheaper CRISPR test? To cassify AS? Could a CRISPR test correlate immune response to TCR/CRISPR? https://www.youtube.com/watch?v=jAhjPd4uNFY What works best (chemo vs other) per immune response DNA?

See Mammoth Bio CRISPR paper test. https://mammoth.bio/ NCGR has trained NHS/UK in DNA diagnostics in this internship. https://www.youtube.com/watch?v=9tUtC4rcZ3w http://www.nminbre.org/index.php/2018-inbre-summer-internshi... I would study Machine Learning as it is now used for DNA. https://github.com/kjaisingh/high-school-guide-to-machine-le... I used AI/shotgun sequencing on the US Human Genome Project.

⬐ rorykoehler

Thanks for all the links and info. I will spend some time exploring them. Much appreciated

https://www.youtube.com/watch?v=jAhjPd4uNFY is also a good explanation from Kurzgesagt

For anyone unfamiliar with CRISPR, I strongly recommend this quick introduction video from Kurzgesagt on YouTube:

https://www.youtube.com/watch?v=jAhjPd4uNFY

⬐ sago

While we're at the video recommendations, it would be remiss to omit

https://www.youtube.com/watch?v=k99bMtg4zRk

As fun as it is, Tim Blais works hard to make hardcore science engaging.

⬐ Jedd

This video was published in 2016-10, and contains this exquisite quote (around 6'):

> In 2015, scientists use CRISPR to cut the HIV virus out of living cells from patients in the lab, proving it was possible. Only a year later they carried out a larger scale project with rats that had the HIV virus <sic> in basically all of their body cells. By simply injecting CRISPR into the rats tails they were able to remove more than 50% of the virus from cells all over the body. In a few decades, a CRISPR therapy might cure HIV and other retroviruses ...

⬐ degenerate

This video is how I originally heard of CRISPR, and it's still the best video I have seen on the subject.

⬐ Mrtierne

One of the best Youtube channels across categories

⬐ lolive

For french users, this basic video describes the principle of CRISPR/CAS9: https://www.youtube.com/watch?v=bYVE05egjPg

⬐ Malic

I'll add a nod to the Kurzgesagt CRISPR video recommendation. It is really nice introduction to the discovery of CAS9, CRISPR as a DNA editing technique, and the fast evolving possibilities of CRISPR.

⬐ DigitalJack

There is a great radiolab podcast on it as well. http://www.radiolab.org/story/update-crispr/

⬐ mino

I wanted to post the same thing. That episode of radiolab was great.

I found this Kurzgesagt video a useful intro to CRISPR: https://www.youtube.com/watch?v=jAhjPd4uNFY

⬐ problems

Radiolab also did a very good job with it: http://www.radiolab.org/story/antibodies-part-1-crispr/

Here's a Kurzgesagt video about CRISPR for anyone that's curious: https://www.youtube.com/watch?v=jAhjPd4uNFY

CRISPR techniques allow for editing genes of adult organisms.

Here's a good video about it: https://www.youtube.com/watch?v=jAhjPd4uNFY

This week's Kurzgesagt episode covered CRISPR in an easy to understand fashion: https://www.youtube.com/watch?v=jAhjPd4uNFY.

⬐ MichaelApproved

World Science Festival talk on CRISPER [1:24:25] https://www.youtube.com/watch?v=Nimj6SNPq-o

⬐ WestCoastJustin

And massive reddit thread about it @ https://www.reddit.com/r/videos/comments/4x1s2k/genetic_engi...

⬐ zeristor

is super soldiers for CRISPR, what alien invasion is for SETI? I loved it up until it went daft.