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Molecular Biology of the Cell, 5th Edition

Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter · 5 HN comments
HN Books has aggregated all Hacker News stories and comments that mention "Molecular Biology of the Cell, 5th Edition" by Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter.
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Amazon Summary
For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book.* And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint® presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies―animations, videos, and molecular models―all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. * There is also a reference edition of Molecular Biology of the Cell, Fifth Edition (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.
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Your best bet is probably to look for a co-founder with an MS or PHD in molecular biology rather than trying to get yourself to that level from the ground up. If you have some biology background and just want to understand the specifics of Crispr, you can start with this paper[0] and just google every term you aren't familiar with until you make it all the way through. If you don't know biology at all, this[1] is a common text book in undergrad programs for molecular/cellular biology.

[0] https://www.ncbi.nlm.nih.gov/pubmed/23287718

[1] https://www.amazon.com/Molecular-Biology-Cell-Bruce-Alberts/...

If you like this book you will probably also like the gold standard for cellular biology: Molecular Biology of the Cell (http://www.amazon.com/Molecular-Biology-Cell-5th-Edition/dp/...).

It costs more but it's worth it. It's a deeply informative book that covers a large spectrum of topics that you can read without much background knowledge in biology. It's the same book your doctor or bioinformatics professional probably used in school learning about cellular biology.

...if you want to learn about the true beauty of viruses, learn about how they work, how their genetic code is written and "executed" to produce the simplest and smallest possible viable replicator (though not an independent replicator), grab a molecular virology textbook like [1] (it's not that hard - you can skim a more general molec bio book like [2], which is written in a style very friendly to all technically oriented people, including coders). Or check out a really cool virology blog - http://www.virology.ws/ (by one of the authors of book [1]), though latest posts are more about politics and social implications than cool basic science.

I have a feeling that von Newman would be extremely fascinated by modern molecular virology if he'd be alive today, considering his interest for minimal universal replicators [3]. If you think about it, modern computer science may very well owe its existence to von Newman's and Turing's interest in mathematical models of life itself!

(...if you want to learn more about the topic above, just google "von newman universal constructor" or "turing morphogenesis" or "schrodinger what is life" and start exploring, I don't want to spoil anyone's fun of finding out about this for yourselves :) )

--- [1] http://astore.amazon.com/virologyws-20/detail/1555814433 [2] http://www.amazon.com/Molecular-Biology-Cell-Bruce-Alberts/d... [3] http://en.wikipedia.org/wiki/Von_Neumann_universal_construct...

One of the guys at SplatSpace[1] who is something of an expert on genetics / biology / biohacking stuff is always recommending people read this book:

Molecular Biology of the Cell

http://www.amazon.com/dp/0815341059/?tag=hyprod-20&hvadi...

It's not on synthetic biology, mind you, but presumably some understanding of the natural biology is a prerequisite to doing the synthetic stuff. Anyway, he works for GSK doing some pretty interesting stuff and is an all around smart guy, so I tend to assume his recommendation is a good one. YMMV.

[1]: http://www.splatspace.org

thronemonkey
+1 for MBOC, it is the best molecular biology textbook there is. Read this book before trying to understand anything else about biological systems.
GregBuchholz
The publisher has a copy of the table of contents and the first chapter as a pdf on the "downloads" tab of:

http://www.garlandscience.com/product/isbn/9780815341055

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